In 1901, J.S. Pughe published an illustration depicting John D. Rockefeller wearing a huge crown, standing on an oil storage tank labeled "Standard Oil" and glaring out at the world. The crown is decked with railroad cars, the names of railroad companies, oil tanks and wells, all topped by the mighty dollar sign. The piece is entitled: "The King of Combinations." In 2009, Bristol-Myers Squibb (BMS) paid $2.4 billion to acquire Medarex, a biotechnology company developing a promising treatment for melanoma. Four years earlier, Japanese pharmaceutical company Ono and Medarex had partnered to research and develop an antibody against the PD-1 receptor as a potential treatment for cancer. The compound they developed was named nivolumab and later branded as Opdivo. In 2011, BMS obtained exclusive worldwide rights to Opdivo except in Japan, Korea, and Taiwan, where Ono retained rights. And in 2014, the FDA granted accelerated approval to Opdivo to treat patients with ...